Liverpool duo Steven Gerrard and Vladimir Smicer are major doubts for Wednesday's clash with Fulham with thigh and ankle injuries respectively.
The Anfield club have the chance to extend their lead at the top of the Premiership to six points again when they entertain The Cottagers, and stand-in boss Phil Thompson will be hoping for a repeat of last season's meeting between the two clubs.
It was 3-0 in Liverpool's favour when they beat Jean Tigana's men in the Worthington Cup, while the Merseysiders won the last league meeting 4-1 back in April 1968.
After Saturday's 2-0 win against Everton, Fulham now sit comfortably in 8th place in the table, some 10 points adrift of Liverpool.
But Thompson is not taking anything for granted, and he said: "It's nice to be at the top of the league but we're not getting carried away.
"There's a long way to go. We enjoy being up there, we are there to be shot at but it is important we don't get carried away and we have been stressing that in the dressing room."
Liverpool are now 17 games unbeaten between them.
Meanwhile Tottenham's Christian Ziege's five bookings mean he is banned from Saturday's clash with Fulham, although his knee injury would have kept him out anyway.
The German star picked up his fifth booking of the season in the Worthington Cup win over Fulham and subsequently has been handed the mandatory one-match ban.