Tottenham Manager Glenn Hoddle is forced to make at least one change for Thursday's trip to Craven Cottage when his side take on in-form Fulham.
Dean Richards is cup-tied having appeared for Southampton in an earlier round against Brighton & Hove Albion whilst influential midfielder Gus Poyet, who sustained a head injury at Upton Park at the weekend is very doubtful.
It's thought that Goran Bunjevcevic will replace Dean Richards whilst Poyet's deputy will depend if Mauricio Taricco recovers from the knock that kept him out Spurs win at West Ham. Should the Argentine miss out Oyvind Leohardsen could well step into Poyet's place in midfield.
Only a last-minute extra-time equaliser from Rufus Brevett saved Fulham in the 2nd round clash at Rochdale.
Louis Boa Morte had seen his early strike cancelled out by Kevin Townson's 75th minute effort, and after Townson had netted again in extra-time the Cottagers looked to heading out. However, Rufus Brevett's sent the tie into a penalty shoot out and Fulham squeezed through 5-6.
Fulham trailed twice in the 3rd round of this competition at home to Derby County, before goals from Barry Hayles, Sylvain Legwinski, John Collins, Louis Saha and a Steed Malbranque penalty saw them win through 5-2.
The best Fulham have achieved in the Worthinghton Cup - in all its guises - is the quarter-finals in 1967-68. Although First Division Fulham were drawn at home to Second Division Huddersfield Town, they could manage only a 1-1 draw and lost the replay 2-1 at Leeds Road.
Spurs have won the competition on three occasions. 1971, 1973 and 1999. Spurs were also runners-up in 1982 losing 3-1 to Liverpool after extra-time.
Fulham and Spurs have met twice before in the League Cup - both times in the 4th round - and the score currently stands at one apiece.
A Micky Hazzard goal was enough to sink Malcolm Macdonald's Third Division Fulham on the 4th December 1981 at White Hart Lane in front of a crowd of 30,124.
Craven Cottage was the venue of the last meeting between the sides on 1/12/99 and 18,134 turned out to see Second Division Fulham send holders Spurs tumbling out of the cup.
Goals from Wayne Collins, Barry Hayles and Geoff Horsfield sank George Graham's Spurs - who could only muster a Steffen Iversen reply.
Spurs have enjoyed a comfortable path to the 4th round and are yet to concede a goal.
Strikes from Ledley King and Les Ferdinand saw Torquay beaten 2-0 at the Lane, while Teddy Sheringham, Darren Anderton, Gustavo Poyet and Sergei Rebrov each scored in the 4-0 trouncing of Tranmere Rovers at Prenton Park.
Key man for Fulham will be Dutch 'keeper Edwin van der Sar. The 6ft 5in former Juventus stopper will be essential in combatting the danger Spurs will present from set-pieces. Spurs will again rely on the intelligence of Teddy Sheringham's link play in their efforts to break down the hosts.
Fulham fans will remember that the last time Sheringham visited the Cottage (with Manchester United) he broke their hearts with a late winner for the Red Devils.
Tickets for Fulham v Tottenham are still available to Club Members and Season Ticket Holders (see ticket news link)