Danish winger Jesper Gronkjaer is in contention for a place in Chelsea's starting line up after playing for more than an hour in the reserve team win over Southampton on Monday.
Goalkeeper Mark Bosnich also played in that game and could feature on the bench.
Fulham's combative midfielder Lee Clark suffered a calf strain on his return from a two month lay-off against Liverpool. But Sean Davis has recovered from a bruised thigh and should play.
Midfielder Sylvain Legwinski is out as he has amassed five yellow cards and will serve a one-match ban.
MOST SIGNIFICANT STATS
The first ever West London Premiership derby at Stamford Bridge.
Fulham make the short journey in the hope of picking up a first away top flight victory over their near neighbours in 38 years.
Chelsea's Slavisa Jokanovic was sent off during the reverse fixture in September, which resulted in a 1-1 draw.
Claudio Ranieri's side are in the midst of three London derbies. This match follows Saturday's visit to Charlton and precedes next Sunday's FA Cup Quarter-final at Tottenham.
Fulham have lost their last three away League games and have not won in four Premiership games on the road, while Chelsea are looking for a seventh successive home clash without defeat.
TOTAL MEETINGS: (52) Chelsea wins 28 Fulham wins 8 Draws 16
HEAD TO HEAD NOTES
Chelsea are unbeaten in 8 League and Cup meetings with Fulham over 22 years.
Fulham's only win in nine League visits to Stamford Bridge over 38 years was 0-2 on 27 October, 1979 in the old League - Division Two.
The Cottagers last and only top flight success at Chelsea was 1-2 on 7 March, 1964.
MAN IN THE MIDDLE PETER JONES Loughborough, Leicestershire.
Chelsea v Fulham and a great betting offer.....
Before Fulham can turn their full attention to this weekend's FA Cup Quarter-Final, there is the small matter of a West London derby to contend with.
These fixtures are notoriously competitive, and Wednesday's meeting is unlikely to be any different with both Fulham and Chelsea looking to put indifferent results behind them.
While Fulham were unlucky to lose against Liverpool at the weekend, their third defeat in a row, Chelsea lived up to their reputation as one of the most unpredictable teams in the Premiership with defeat at the Valley. It was the second time Chelsea had lost to Charlton this season, and Jean Tigana will be looking to emulate that performance on Wednesday. A Fulham 2-1 win is priced at 16/1.
A £10 bet with Fulham Bet would win you £160.
Scoring goals remains Fulham's biggest problem, however, but the number of chances they created against Liverpool does offer some encouragement. If Charlton can end a goal-less spell of 6 hours against the Blues, surely the Cottagers can hit the back of the net at least once.....? A Draw/Fulham double result is priced at 11/1
A £10 bet with Fulham Bet would win you £110.
Regardless of the manner of victory, if the Blues are humbled at the Bridge, Fulham Bet will give new registrants £20. All you have to do is register and place a £5 bet on the game.*
To view an unrivalled range of markets, visit Fulham Bet. (*Terms and conditions apply. Visit Fulham Bet for full details)