Josh Pritchard started and George Williams made his Wales Under-21 debut as a late substitute in their 1-0 European Championship Qualifiers Group 1 loss to England on Wednesday night.
Both sides had chances to take the lead during an even opening half in Derby, but Nathan Redmond's powerful effort in the 56th minute sealed victory to send Gareth Southgate's men six points clear.
Williams was introduced in the 83rd minute for Fulham teammate Pritchard.
Lasse Vigen Christensen played the full 90 minutes and grabbed a brace as Denmark Under-21s ripped nine-man Estonia apart in Group 2 with an 8-0 victory.
The rout began when the Fulham man was fouled in the penalty area with just 12 minutes played. Estonia defender Aleksandr Kulinitš was dismissed for the offence and Pierre Højbjerg made no mistake from the spot.
Just three minutes later it was 2-0, with Estonia again having a man sent off for a foul in the area. This time Højbjerg saw his kick saved, but was on hand to finish off the rebound.
Former Cardiff City striker Andreas Cornelius grabbed a third shortly after, with Yussuf Poulsen and Nicolaj Thomsen adding to the scoreline after half-time. Christensen then bagged his first of the evening on 67, with Thomsen notching his second and Denmark’s seventh four minutes later.
And, with six minutes remaining, Christensen had the final say with his second of the night as Denmark maintained their unbeaten campaign in style.
In Group 9, Marcello Trotta and Liam Donnelly went up against each other but it was the striker who came out on top as Italy beat Northern Ireland 2-0, with the on-loan Brentford man notching the second goal.
Donnelly played the entire game while Trotta entered the action as a 56th-minute substitute, with Italy then taking the lead just before the hour through Daniele Rugani. The Italians got a deserved second when Trotta netted in the 89th minute. The result leaves Italy third and Northern Ireland bottom of the group.
Pajtim Kasami captained Switzerland to a comfortable 5-1 victory over Liechtenstein in Group 5, scoring a fine goal to cap an excellent evening’s work.
Pierluigi Tami's team led 3-0 at half-time through Remo Freuler, Kasami and Michael Frey, before Silvan Widmer stretched the lead further four minutes after the restart. Simon Kühne pulled one back for the visitors, before Haris Tabakovic completed the scoring in added time to leave the Swiss three points behind Croatia.
Jack Grimmer made his Scotland Under-21s debut as a 57th-minute in their 2-2 friendly draw with Hungary at Tannadice. Callum McGregor put Scotland in front after 25 minutes with a low free-kick and Ryan Fraser tapped home their second just before the break. Hungary pulled one back from the spot on 68 through Rado and the same player grabbed an equaliser with just three minutes remaining.
Cameron Burgess played the full 90 as Scotland Under-19s won 4-2 against Switzerland in Livingston.