Peter Grant’s Under-23 host Brighton and Hove Albion on Friday evening at Motspur Park in a 7pm kick off.
Fulham are fifth in the PL2 Division 2 and are pitted against the Seagulls who are one spot and three points behind the Whites.
Fulham are in a fine fettle of form having won their last five consecutive league matches.
Brighton are also a form team, undefeated in their last six league matches with three wins and three draws. However, on Monday evening the Seagulls lost 4-1 in the Premier League Cup in a heavy away loss at Exeter City.
Last time out the Under-21s beat Crawley 3-1 in the Checkatrade Trophy, with Jordan Graham grabbing a brace and Elijah Adebayo getting his 10th goal of the season.
Victory on Friday would give the Whites a five-point cushion in the play-off spots, and could potentially lift them to fourth in the table. However, a win for Brighton would see them leapfrog Fulham.
The two sides have already played once this season in the reverse fixture. Brighton won that encounter 4-2.
This match will be streamed live on fulhamfctv for subscribers, alternatively there will be live updates on the Club’s official twitter account, @FulhamFC.